Master of Science
Patty Fu-Giles, Ph.D.
Walter Henne, Jr., Ph.D.
Karen D'Arcy, Ph.D.
An injury to the skin alters the integrity of underlying tissues and microcirculation and thus certainly culminates in a wound. Wound healing is a highly complex, dynamic, interactive and well regulated physiological process involving blood cells, extracellular matrix, parenchyma cells and soluble mediators. It starts with alteration in integrity of tissues and ends with the formation of scar. The process of wound healing is distinguished into Haemostasis, Inflammation, Proliferation and Remodeling. Various cells like platelets, neutrophils, macrophages, lymphocytes, angiocytes, keratinocytes, fibroblasts and factors like platelet derived growth factor, transforming growth factor, platelet derived epidermal growth factors, fibroblasts growth factor, albumin, fibrinogen, fibronectin, anti hemophilic factor, pro accelerin etc play a significant role in wound formation and its amelioration at some crucial points for a brief period of time. Management of chronic wounds requires the use of antimicrobial application so as to eliminate the bacterial colonial biofilm formation at the injury which hinders the recovery. Different pathological parameter serves as biomarker for the evaluation and assessment of wound severity, measure to take care and the alternatives to be needed. Thus timely accurate and precise wound care may prevent the bio burden in the wound and the various sufferings to the patient.
Khan, Mujtaba, "Wound Healing and the Role of Biomarkers and Biofilms" (2011). All Capstone Projects. 56.