Title

Vitamin Receptor Mediated Endocytosis as a Tumor-Targeting Drug Delivery System

Publication Date

2012

Document Type

Project Summary

Degree Name

Master of Science

Department

Analytical Chemistry

First Advisor

Dr. Aheda Saber

Second Advisor

Dr Patty Fu

Third Advisor

Dr Karen D'arcy

Abstract

Vitamins such as folic acid and biotin are used as targeting agents in tumor targeted drug delivery system. The process of drug delivery takes place through Endocytosis. Vitamins are conjugated to cytotoxic agent with the help of a linker. This mechanism based vitamin receptor mediated drug delivery system is tumor specific and highly efficient. The sequence of events involved are validated and monitored with fluorescent probes using confocal fluorescence microscopy (CFM). This mechanism based tumor-targeting drug delivery system will find a wide range of applications. The problem of systemic cytotoxicity involved with conventional chemotherapy can be avoided using this drug delivery system. This literature review gives a basic outline of the process of vitamin receptor mediated Endocytosis as a tumor targeting drug delivery system.

Comments

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