Inverted Micelles for Ocular Drug Delivery
Master of Science
The purpose of developing this unique nanoparticulate system using inverted micelles is to provide prolonged delivery of antibiotics in a therapeutically relevant concentration to the eyes. Lacrimation and impermeability through the corneal epithelium are the primary factors responsible for poor ocular bioavailability. The usage of inverted micelles as nanoparticles in this system can possibly overcome this challenge. In an inverted micelle, the polar groups of the surfactants are concentrated in the interior and the lipophilic groups extend toward and into the nonpolar solvent. This property helps in the encapsulation of both hydrophilic and hydrophobic drugs. This invention involves three major components: Encapsulating both hydrophilic and hydrophobic drugs into the inverted micelles. Secondly incorporating these inverted micelles into the polymeric coating material with a volatile carrier solvent. Finally it involves the application of this product onto the intraocular lenses. When the volatile carrier solvent evaporates, the coated polymer within the micelles will form a thin film coat on the intraocular lens. Intraocular lenses formulated using this technology help in the successful controlled delivery of the ophthalmic medication for the prevention and treatment of eye diseases.
Gangu, Prathyusha, "Inverted Micelles for Ocular Drug Delivery" (2012). All Capstone Projects. 412.