Publication Date

Spring 2013

Document Type


Degree Name

Master of Science


Analytical Chemistry

First Advisor

Walter Henne, Jr., Ph.D.

Second Advisor

Piotr Grzyska, Ph.D.

Third Advisor

Aheda Saber, Ph.D.


Mass spectral imaging (MS-imaging) is a modern technique used for the analysis and characterization and distribution of pharmaceutical ingredients , drugs, peptidies, lipids, and other bioactive species in tissue section/ Tissue prints. Although now widely accepted, there remains a host of competing and complementary techniques including DESI, MALDI, SIMS, and DART ionization techniques that allow the researchers to obtain appreciable ion intensities for mapping purposes. Instrumentation further is, rapidly advancing with significant progress in TOF, ion trap, and quadrupole instrumentation for mapping. In this review, I will examine the current status and role of MS-imaging with emphasis on analysis of pharmaceutical ingredients.


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