Publication Date

Summer 2012

Document Type

Project Summary

Degree Name

Master of Science


Analytical Chemistry

First Advisor

Patty Fu-Giles, Ph.D.

Second Advisor

Karen D'Arcy, Ph.D.

Third Advisor

Joseph B. Addison, Ph.D.


The objective of this study is to use DLS (Dynamic Light Scattering) to analyze polymeric copper phthalocyanine nanoparticles (CuPcNPs). CuPcNPs are synthesized in order to facilitate drug penetration of bacterial biofilms for the treatment of chronic wounds. Microorganisms that reside inside the biofilms of chronic wounds are very resistant to any kind of treatment, even to the host’s own immune system. Therefore we have proposed an alternative method to destroy the microorganisms existing within the biofilms. Photodynamic anti-bacterial chemotherapy (PACT) has received much attention for the past decade due to the multi-drug resistant strands. PACT uses photons, a photosensitizer, and a reactive oxygen species to eliminate both Gram+ and Gram- bacteria. In this study, the hydrophobic photosensitizer phthalocyanine has been encapsulated inside the polymetric nanoparticles and the sizes of the nanoparticles are determined using DLS technique.