Master of Science
Patty Fu-Giles, Ph.D.
Karen D'Arcy, Ph.D.
Xiaoyong Chen, Ph.D.
Biofilms are now considered ubiquitous in the natural world. Bacterial biofilms have been observed to be extremely heterogeneous, both structurally and with regard to the physiology of the bacterial cells within them. The prevailing conceptual model depicts bacterial biofilms as being made up of microcolonies, which serve as the basic unit of the greater biofilm structure. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. A number of elements in the process of biofilm formation have been studied as targets for novel drug delivery technologies. The present study aimed to penetrate biofilm by gram positive and gram negative bacteria by in-vitro culture technique, with developed nano emulsion containing photodynamic agents. The results of this study are encouraged and significantly prevent the formation of microcolonies, building blocks of biofilms.
Chavala, Arunakanth, "Nano Encapsulated Drug Delivery for Biofilms" (2012). All Capstone Projects. 61.