Master of Science
Shailendra Kumar, Ph.D.
Karen D'Arcy, Ph.D.
Patty Fu-Giles, Ph.D.
The NIH shift is a chemical shift of substituents in aromatic hydroxylation reactions. The substituents that undergo this shift are hydrogen, halogens, acyl and alkyl groups. It is an important aspect that is a requirement in the hydroxylation of aromatic compounds by monooxygenase enzymes.
The NIH shift or the National Institute of health shift gets its name from the founders of this mechanism. The National Institute of Health was the first to observe this phenomenon in there studies and are the first to report this chemical shift.
Owens, Nicole, "NIH Shift Literature Search" (2012). All Capstone Projects. 72.