Publication Date

Summer 2012

Document Type

Project Summary

Degree Name

Master of Science


Analytical Chemistry

First Advisor

Shailendra Kumar, Ph.D.

Second Advisor

Karen D'Arcy, Ph.D.

Third Advisor

Patty Fu-Giles, Ph.D.


The NIH shift is a chemical shift of substituents in aromatic hydroxylation reactions. The substituents that undergo this shift are hydrogen, halogens, acyl and alkyl groups. It is an important aspect that is a requirement in the hydroxylation of aromatic compounds by monooxygenase enzymes.

The NIH shift or the National Institute of health shift gets its name from the founders of this mechanism. The National Institute of Health was the first to observe this phenomenon in there studies and are the first to report this chemical shift.


Abstract created from manuscript by OPUS staff.

Owens_Nicole_Summary.pdf (159 kB)