Publication Date

Summer 2017

Document Type

Project Summary

Degree Name

Master of Science

Department

Analytical Chemistry

First Advisor

K. G. Sanjaya Ranmohotti, Ph.D.

Second Advisor

Donald Culverson, Ph.D.

Third Advisor

Susan Gaffney, Ph.D.

Abstract

(FR) is overexpressed on the cell membrane in cancer tissues and activated macrophages associated with rheumatoid conditions. However, FR is restricted in normal healthy tissues. Folic acid has shown high affinity to folate receptors and thus can be used in targeting the tumor cells. Folic acid residue, pteroic acid is also used in several studies that are involved in targeting cancer cells. Several examples include technetium -99m radiotracer labelled pteroyl-lys conjugates, pteroic acid-conjugated nitroheterocyclic phosphoramidates..

In this project, we were successfully able to conjugate pteroic acid with polyethylene Glycol-Amine to create an elegant building block(pte-PEG-amine) for synthesis of future imaging agents. The compound was purified and analytically tested by HPLC (High Pressure Liquid Chromatography) and MS (Mass spectrometry) supporting successful synthesis and purification.

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