Vitamin Receptor Mediated Endocytosis as a Tumor-Targeting Drug Delivery System
Publication Date
2012
Document Type
Project Summary
Degree Name
Master of Science
Department
Analytical Chemistry
First Advisor
Dr. Aheda Saber
Second Advisor
Dr Patty Fu
Third Advisor
Dr Karen D'arcy
Abstract
Vitamins such as folic acid and biotin are used as targeting agents in tumor targeted drug delivery system. The process of drug delivery takes place through Endocytosis. Vitamins are conjugated to cytotoxic agent with the help of a linker. This mechanism based vitamin receptor mediated drug delivery system is tumor specific and highly efficient. The sequence of events involved are validated and monitored with fluorescent probes using confocal fluorescence microscopy (CFM). This mechanism based tumor-targeting drug delivery system will find a wide range of applications. The problem of systemic cytotoxicity involved with conventional chemotherapy can be avoided using this drug delivery system. This literature review gives a basic outline of the process of vitamin receptor mediated Endocytosis as a tumor targeting drug delivery system.
Recommended Citation
Bandi, Shiva Rahul, "Vitamin Receptor Mediated Endocytosis as a Tumor-Targeting Drug Delivery System" (2012). All Capstone Projects. 389.
https://opus.govst.edu/capstones/389
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