"Method Development and Analysis for Pharmaceuticals and Personal Care " by Victoria Ruelas

Publication Date

Spring 2014

Document Type

Project Summary

Degree Name

Master of Science

Department

Analytical Chemistry

First Advisor

Karen D'Arcy, Ph.D.

Second Advisor

Stephen Kent, M.B.A.

Third Advisor

Joong-Won Shin, Ph.D.

Abstract

Pharmaceuticals and Personal Care Products (PPCP) in surface waters is a worldwide concern. Effluent from waste water treatment plants have tested positive for PPCP. Method development for a liquid chromatographic method was derived using columns with fused core technology. Analysis of spiked samples as direct injection and after solid phase extraction indicated detection of acetaminophen, caffeine, bisphenol-A and triclosan. Confirmation of acetaminophen, caffeine, bisphenol-A and triclosan was achieved using Agilent 1100 HPLC with Agilent MST Trap XCT. Solid phase extraction using Oasis HLB indicated reproducibility at 0.05ppm.

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