Publication Date
Spring 2012
Document Type
Project Summary
Degree Name
Master of Science
Department
Analytical Chemistry
First Advisor
Walter Henne, Jr., Ph.D.
Second Advisor
Patty Fu-Giles, Ph.D.
Third Advisor
Stephen Kent, M.B.A.
Abstract
The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate receptor positive cancer cells. In this review I will examine the current status and role of folate targeted nanoconjugates for both diagnostic imaging and therapy.
Recommended Citation
Masood, Safwat A., "Folate Nanoparticle Conjugates" (2012). All Capstone Projects. 59.
https://opus.govst.edu/capstones/59