Publication Date

Summer 2012

Document Type

Project Summary

Degree Name

Master of Science

Department

Analytical Chemistry

First Advisor

Patty Fu-Giles, Ph.D.

Second Advisor

Karen D'Arcy, Ph.D.

Third Advisor

Xiaoyong Chen, Ph.D.

Abstract

The purpose of this study is to develop a unique nanoparticulated system that has the capability of providing sustained drug delivery into the eyes. In ophthalmic preparations, poor ocular drug delivery of ocular dosage form is due to the production of tears and impermeability through corneal epithelium. The usage of liposomes in ophthalmic disorders shows promising results in ocular drug delivery. Liposomes are bilayered, microscopic vesicles surrounded by the aqueous compartments. Liposomes have the ability to encapsulate both hydrophilic and hydrophobic drugs. This unique property of liposomes helps in delivering the drug at specific site. This invention involves three major components: first, encapsulating of both hydrophilic and hydrophobic drugs into the liposomes. Second, incorporate liposomes into polymeric coating material with a volatile carrier solvent. Finally, apply liposome incorporated coating composite into intraocular lenses. When volatile solvent evaporates, the coated polymer with liposomes will form a thin film upon the intraocular lens. Local application of encapsulated coated intraocular lenses helps in the successful controlled, sustained time release of the drug in to the target site helps in prevention and treatment of ophthalmic diseases.

Comments

Correct spelling of thesis title is Nanoparticulated Drug Delivery System for Vitreous Humor.

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